Tandem Reactions for Streamlining Synthesis: Enantio- and Diastereoselective One-Pot Generation of Functionalized Epoxy Alcohols
نویسندگان
چکیده
منابع مشابه
Enantio- and diastereoselective synthesis of γ-amino alcohols.
The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N-PMP-protected γ-amino alcohols from the corresponding ketones. The anti-products were obtained through Ir-catalyzed asymmetric transfer hydrogenation, the syn-products via Rh-catalyzed asymmetric hydrogenation.
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2008
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar800006h